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Effect of Rimonabant on Body Weight and the Metabolic Syndrome in Overweight Patients. Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study. 16 issue of the British Medical Journal, Padwal's team found that long-term users of weight-loss drugs such as orlistat (Xenical), sibutramine (Meridia) and rimonabant experienced only modest weight loss -- less than 11 pounds, which was less than 5 percent of their total body weight. Food and Drug Administration (FDA) Endocrinologic and Metabolic Drugs Advisory Committee did not recommend approval of rimonabant (Zimulti / Accomplia) to the US FDA. 25 percent increase in percent atheroma volume (PAV) in those taking rimonabant, compared to 0. Rimonabant is not yet approved for use in the United States, where it is known as Zimulti.

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